diff --git a/tests/e2e/offline_inference/test_minicpmo_4_5.py b/tests/e2e/offline_inference/test_minicpmo_4_5.py
index ee1dc4d01..fe7a2d2be 100644
--- a/tests/e2e/offline_inference/test_minicpmo_4_5.py
+++ b/tests/e2e/offline_inference/test_minicpmo_4_5.py
@@ -31,6 +31,7 @@ def get_question(prompt_type: str = "text") -> str:
     return prompts.get(prompt_type, prompts["text"])
 
 
+@pytest.mark.skip(reason="https://github.com/vllm-project/vllm-omni/issues/5437")
 @pytest.mark.core_model
 @pytest.mark.advanced_model
 @pytest.mark.omni
@@ -87,6 +88,7 @@ def test_text_to_audio(omni_runner, omni_runner_handler) -> None:
     omni_runner_handler.send_omni_request(request_config)
 
 
+@pytest.mark.skip(reason="https://github.com/vllm-project/vllm-omni/issues/5437")
 @pytest.mark.core_model
 @pytest.mark.advanced_model
 @pytest.mark.omni
diff --git a/tests/e2e/online_serving/test_minicpmo_4_5.py b/tests/e2e/online_serving/test_minicpmo_4_5.py
index 7d2c7948e..f875c00d8 100644
--- a/tests/e2e/online_serving/test_minicpmo_4_5.py
+++ b/tests/e2e/online_serving/test_minicpmo_4_5.py
@@ -65,6 +65,7 @@ def get_max_batch_size(size_type="few"):
     return batch_sizes.get(size_type, 5)
 
 
+@pytest.mark.skip(reason="https://github.com/vllm-project/vllm-omni/issues/5437")
 @pytest.mark.core_model
 @pytest.mark.advanced_model
 @pytest.mark.omni
@@ -200,6 +201,7 @@ def test_video_to_text_audio_001(omni_server, openai_client) -> None:
     openai_client.send_omni_request(request_config, request_num=get_max_batch_size())
 
 
+@pytest.mark.skip(reason="https://github.com/vllm-project/vllm-omni/issues/5437")
 @pytest.mark.core_model
 @pytest.mark.advanced_model
 @pytest.mark.omni